ムラヤマ ノリオ
Murayama Norio
村山 憲男 所属
人間社会学部 心理学科
生活機構研究科 心理学専攻
生活心理研究所 所属教員
生活機構研究科 生活機構学専攻
職種
准教授
|
|
言語種別 | 英語 |
発行・発表の年月 | 2010/12 |
形態種別 | 学術雑誌 |
査読 | 査読あり |
標題 | Distribution of cerebral amyloid deposition and its relevance to clinical phenotype in Lewy body dementia |
執筆形態 | 共著 |
掲載誌名 | Neuroscience Letters |
掲載区分 | 国外 |
巻・号・頁 | 486,pp.19-23 |
著者・共著者 | Hiroshige FUJISHIRO, Eizo ISEKI, Shinji HIGASHI, Koji KASANUKI, Norio MURAYAMA, Takashi TOGO, Omi KATSUSE, Hirotake UCHIKADO, Naoya AOKI, Kenji KOSAKA, Heii ARAI, Kiyoshi SATO |
概要 | Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) are clinically distinguished based only on the duration of parkinsonism prior to dementia. It is known that there is considerable pathological overlap between these two conditions, but the pathological difference between them remains unknown. We evaluated Alzheimer-type pathology in 30 brains of patients with Lewy body dementia using standardized methods based on those of the Brain-Net Europe (BNE) Consortium. Only 2 of 13 PDD cases (15%) showed Aβ-immunoreactive pathology in the midbrain (amyloid phase IV). In contrast, 12 of 17 DLB cases (71%) exhibited midbrain involvement. Four of the DLB cases (24%) but none of the PDD cases exhibited Aβ-immunoreactive pathology in the cerebellum (amyloid phase V). The ratio of cases with subtentorial involvement of amyloid deposition was significantly higher in DLB than in PDD. The median of amyloid phases was significantly greater in DLB than in PDD, but there was no difference in neurofibrillary tangle (NFT) Braak stages or in Lewy body scores. When patients were classified according to whether dementia or parkinsonism had occurred first, the rate of dementia having occurred first was significantly greater in amyloid phase IV and V than in phase 0-I, with phase III in the middle, though there was no significant difference in median NFT Braak stage or mean Lewy body score associated with amyloid phase. These results suggest that amyloid deposition may contribute to the timing of the onset of dementia relative to that of parkinsonism in Lewy body dementia. |