教員紹介・研究業績 - 島村　達郎

シマムラ　タツロウ Simamura Tatsuro
島村　達郎

所属食健康科学部食安全マネジメント学科

職種教授

著書・論文歴
1.	2023/04	論文	Structure and mechanism of oxalate transporter OxlT in an oxalate-degrading bacterium in the gut microbiota. Nat Commun. 14 (1),1730 (共著)
2.	2022/06	著書	GPCRの構造解析研究構造生命科学による創薬への挑戦 (共著)
3.	2021/12	著書	X線自由電子レーザーを用いたタンパク質の構造解析創薬研究のための相互作用解析パーフェクト (共著)
4.	2021/08	論文	GPCRの構造解析研究医学のあゆみ 278,573-579頁 (単著)
5.	2021/08	論文	S1PR3-G12-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation. Cell Chem Biol. 28 (8),1132-1144頁 (共著)
6.	2021/03	論文	Time-resolved serial femtosecond crystallography reveals early structural changes in channelrhodopsin. Elife 10 (e62389) (共著)
7.	2020/12	論文	Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone. Nat Commun. 11 (6442) (共著)
8.	2020/04	論文	The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone. Structure 28 (4),418-425頁 (共著)
9.	2019/10	論文	High-viscosity sample-injection device for serial femtosecond crystallography at atmospheric pressure. J. Appl. Cryst. 52 (6),1280-1288頁 (共著)
10.	2019/09	論文	5-HT2A受容体の構造から解明された薬剤の受容体選択機構医学のあゆみ 270,1152-1153頁 (単著)
11.	2019/09	論文	Structural basis for the substrate recognition of aminoglycoside 7"-phosphotransferase-Ia from Streptomyces hygroscopicus. Acta Crystallogr Sect F Struct Biol Cryst Commun. 75 (9),599-607頁 (共著)
12.	2019/02	論文	Structures of the 5-HT2A receptor in complex with the antipsychotics risperidone and zotepine. at Struct Mol Biol. 26 (2),121-128頁 (共著)
13.	2018/12	著書	Structure, Substrate Recognition, and Mechanism of the Na+-Hydantoin Membrane Transport Protein, Mhp1 Encyclopedia of Biophysics (共著)
14.	2018/07	論文	Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog. Nat Struct Mol Biol. 25 (7),570-576頁 (共著)
15.	2018/01	論文	Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA. Structure. 26 (1),7-19頁 (共著)
16.	2016/12	論文	A three-dimensional movie of structural changes in bacteriorhodopsin. Science 354 (6319),1552-1557頁 (共著)
17.	2016/11	論文	Membrane protein structure determination by SAD, SIR, or SIRAS phasing in serial femtosecond crystallography using an iododetergent. Proc Natl Acad Sci USA. 113 (46),13039-13044頁 (共著)
18.	2016/10	論文	High-resolution crystal structure of the therapeutic antibody pembrolizumab bound to the human PD-1. Sci Rep. 6 (35297) (共著)
19.	2016/03	論文	Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance. Nat.Commun. 7 (11030) (共著)
20.	2015/12	論文	De novo native sulfur/chlorine SAD phasing for serial femtosecond crystallography. Acta Crystallogr Sect D: Biol Crystallogr. 71 (12),2519-2525頁 (共著)
21.	2015/10	論文	Structure and transport mechanism of the mammalian fructose transporter GLUT5. Nature 526 (7573),397-401頁 (共著)
22.	2015/08	論文	シリアルフェムト秒結晶構造解析のための試料調製法：バッチ法による微結晶化と高粘度媒体を利用した結晶送液方法について蛋白質科学会アーカイブ e081,1-10頁 (共著)
23.	2015/05	論文	Diverse application platform for hard X-ray diffraction in SACLA(DAPHNIS): application to serial protein crystallography using an X-ray free-electron laser. J. Synchrotron. Radiat. 22 (3),532-537頁 (共著)
24.	2015/01	論文	Grease matrix as a versatile carrier of proteins for serial crystallography. Nat Methods. 12 (1),61-63頁 (共著)
25.	2014/12	論文	Proteoliposome-based Selection of a Recombinant Antibody Fragment Against the Human M2 Muscarinic Acetylcholine Receptor. Monoclon Antib Immunodiagn Immunother. 33 (6),378-385頁 (共著)
26.	2014/10	著書	Overview of membrane protein purification and crystallization. Advanced Methods in Structural Biology (共著)
27.	2014/10	論文	Crystal structure of a symmetric football-shaped GroEL:GroES2-ATP14 complex determined at 3.8Å reveals rearrangement between two GroEL rings. J Mol Biol. 426 (21),3634-3641頁 (共著)
28.	2014/07	論文	ヒスタミンH１受容体の構造日本薬理学会誌 144 (1),43-44頁 (単著)
29.	2013/10	著書	ヒスタミン受容体膜タンパク質構造研究 (共著)
30.	2013/02	著書	Mhp1, the Na+-hydantoin membrane transport protein. Encyclopedia of Biophysics (共著)
31.	2012/12	論文	創薬ターゲット膜蛋白質の立体構造解析内分泌・糖尿病・代謝内科 35,557-564頁 (共著)
32.	2012/11	論文	構造生物学と分子標的日本臨床 70 (8),316-320頁 (共著)
33.	2012/09	論文	Conformational transition of the lid helix covering the protease active site is essential for the ATP-dependent protease activity of FtsH. FEBS Lett. 586 (9),3117-3121頁 (共著)
34.	2012/09	論文	ヒト由来ヒスタミンH1受容体の結晶構造の決定生化学 84,772-776頁 (単著)
35.	2012/06	論文	Platform for the rapid construction and evaluation of GPCRs for crystallography in Saccharomyces cerevisiae. Microb Cell Fact. 11 (78) (共著)
36.	2012/01	論文	G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody. Nature 482 (7384),237-240頁 (共著)
37.	2011/12	論文	Crystal　structure-based　virtual screening for fragment-like ligands of the human histamine H1 receptor J. Med. Chem. 54 (23),8195-8206頁 (共著)
38.	2011/12	論文	Production of the stable human histamine H₁ receptor in Pichia pastoris for structural determination. Methods. 55 (4),281-286頁 (共著)
39.	2011/11	論文	ヒスタミンH1受容体の立体構造解明と創薬への期待日本医事新報 4564,50-51頁 (単著)
40.	2011/09	論文	Cloning,expression and purification of the anion exchanger 1 homologue from the basidiomycete Phanerochaete chrysosporium. Protein Expr Purif. 79 (1),81-87頁 (共著)
41.	2011/06	論文	Structure of the human histamine H1 receptor complex with doxepin. Nature 475 (7354),65-70頁 (共著)
42.	2011/04	論文	Crystal structure of glucansucrase from the dental caries pathogen Streptococcus mutans. J Mol Biol. 408 (2),177-186頁 (共著)
43.	2011/04	論文	Evaluation of the Pichia pastoris expression system for the production of GPCRs for structural analysis. Microb Cell Fact. 10 (24),1-13頁 (共著)
44.	2011/01	論文	Cysteine-to-serine shuffling using a Saccharomyces cerevisiae expression system improves protein secretion: case of a nonglycosylated mutant of miraculin,a taste-modifying protein. Biotechnol Lett. 33 (1),103-107頁 (共著)
45.	2011/01	論文	The alternating access mechanism of transport as observed in the sodium-hydantoin transporter Mhp1. J Synchrotron Radiat. 18 (1),20-23頁 (共著)
46.	2011/01	論文	ヒダントイン輸送体に見る膜輸送機構の構造基盤生物物理 51,4-9頁 (共著)
47.	2010/12	著書	The Nucleobase-Cation-Symport-1 family of Membrane Transport Proteins.Part 11. Sodium and Potassium. Handbook of Metalloproteins (共著)
48.	2010/10	論文	立体構造より明らかとなったヒダントイン輸送体Mhp１の輸送機構実験医学 28,2639-2642頁 (共著)
49.	2010/09	論文	Crystallization and preliminary X-ray analysis of a glucansucrase from the dental caries pathogen Streptococcus mutans. Acta Crystallogr Sect F Struct Biol Cryst Commun. 66 (9),1086-1088頁 (共著)
50.	2010/06	論文	Bulky high- mannose-type N-glycan blocks the taste- modifying activity of miraculin. Biochim Biophys Acta. 1800 (9),986-992頁 (共著)
51.	2010/04	論文	Molecular basis of alternating access membrane transport by the sodium-hydantoin transporter Mhp1. Science. 328 (5977),470-473頁 (共著)
52.	2010/04	論文	The catalytic efficiency (kcat/Km) of the class A beta- lactamase Toho-1 correlates with the thermal stability of its catalytic intermediate analog. Biochim Biophys Acta. 1804 (4),684-691頁 (共著)
53.	2009/05	論文	Fluorescence-based optimization of human bitter taste receptor expression in Saccharomyces cerevisiae. iochem Biophys Res Commun. 382 (4),704-710頁 (共著)
54.	2009/04	論文	Improvement of crystal quality by surface mutations of beta-lactamase Toho-1. Acta Crystallogr Sect F Struct Biol Cryst Commun. 65 (4),379-382頁 (共著)
55.	2009/03	論文	Comparison of functional non-glycosylated GPCRs expression in Pichia pastoris. Biochem Biophys Res Commun. 380 (2),271-276頁 (共著)
56.	2008/11	論文	Crystallization of the hydantoin transporter Mhp1 from Microbacterium liquefaciens. Acta Crystallogr Sect F Struct Biol Cryst Commun. 64 (12),1172-1174頁 (共著)
57.	2008/10	論文	Structure and molecular mechanism of a nucleobase-cation- symport-1 family transporter. Science 322 (5902),709-713頁 (共著)
58.	2008/07	論文	Advanced method for high-throughput expression of mutated eukaryotic membrane proteins in Saccharomyces cerevisiae. Biochem Biophys Res Commun. 371 (4),841-845頁 (共著)
59.	2008/07	論文	Molecular mechanism of energy conservation in polysulfide respiration. Nat Struct Mol Biol. 15 (7),730-737頁 (共著)
60.	2008/06	論文	Crystal structure of squid rhodopsin with intracellularly extended cytoplasmic region. J Biol Chem. 283 (26),17753-17756頁 (共著)
61.	2007/08	論文	Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis. Nature. 448 (7153),609-612頁 (共著)
62.	2007/01	論文	Structure of a hyperthermophilic archaeal homing endonuclease, I-Tsp061I:contribution of cross-domain polar networks to thermostability. J Mol Biol. 365 (2),362-378頁 (共著)
63.	2006/01	論文	Leu309 plays a critical role in the encapsulation of substrate protein into the internal cavity of GroEL. J Biol Chem. 281 (2),962-967頁 (共著)
64.	2004/08	論文	Crystal structure of the native chaperonin complex from Thermus thermophilus revealed unexpected asymmetry at the cis-cavity. Structure 12 (8),1471-1480頁 (共著)
65.	2004/05	論文	Crystallization and preliminary X-ray analysis of pseudo-merohedrally twinned crystals of the full-length beta2 subunit of the Kv1 K+ channel from Rattus norvegicus. Acta Crystallogr D Biol Crystallogr. 60 (5),912-914頁 (共著)
66.	2004/03	著書	Structures of Bacterial Heme-Copper Oxidases. Respiration in Archaea and Bacteria: Diversity of Prokaryotic Electron Transport Carriers. (共著)
67.	2003/09	論文	Crystallization of the chaperonin GroEL-GroES complex from Thermus thermophiles HB8. Acta Crystallogr D Biol Crystallogr. 59 (9),1632-1634頁 (共著)
68.	2002/11	論文	Acyl-intermediate structures of the extended-spectrum class A beta-lactamase, Toho-1, in complex with cefotaxime, cephalothin,and benzylpenicillin. J Biol Chem 277 (48),46601-46608頁 (共著)