カワサキ　ヒロアキ    KAWASAKI Hiroaki
   川崎　広明
   所属
食健康科学部 管理栄養学科
 
女性健康科学研究所 所属教員
   職種
准教授
言語種別 英語
発行・発表の年月 2018/11
形態種別 学術雑誌
査読 査読あり
標題 Tryptophan nitration of immunoglobulin light chain as a new possible biomarker for atopic dermatitis.
執筆形態 共著
掲載誌名 J Clin Biochem Nutr.
掲載区分国外
巻・号・頁 63,pp.197-204
著者・共著者 Iizumi K, Kawasaki H, Shigenaga A, Tominaga M, Otsu A, Kamo A, Kamata Y, Takamori K, Yamakura F.
概要 In this study, we attempted to detect a candidate biomarker of early stage atopic dermatitis by focusing on the levels of nitrated residues in the plasma proteins of atopic dermatitis model mice (NC/Nga mice). We found that the immunoglobulin (Ig) light chain was more highly nitrated in the plasma of the animal model than that of control mice. Western blot analysis showed a statistically significant difference between the 6-nitrotryptophan content of the Ig light chain in the NC/Nga mice before onset of atopic dermatitis symptoms and that of the control mice. Our findings suggest that the 6-nitrotryptophan content of Ig light chains could be a new biomarker for detecting early stage atopic dermatitis.