カワサキ ヒロアキ    KAWASAKI Hiroaki
   川崎 広明
   所属
生活科学部 管理栄養学科
   職種
専任講師
言語種別 英語
発行・発表の年月 2016/08
形態種別 学術雑誌
査読 査読あり
標題 Peroxynitrite-mediated oxidation of plasma fibronectin.
執筆形態 共著
掲載区分国外
出版社・発行元 Free Radic. Biol. Med.
巻・号・頁 97,pp.602-615
著者・共著者 Degendorfer G, Chuang CY, Kawasaki H,Hammer A, Malle E, Yamakura F, Davies MJ.
概要 In this study, we revealed that Tyr and Trp residues on human fibronectin, which is a large dimeric glycoprotein present in both human plasma and in basement membranes, had highly sensitive to peroxynitrite with this resulting in the formation of 6-nitrotryptophan and some oxidative modifications as well as protein aggregation and fragmentation.