イケダ タカコ    IKEDA Takako
   池田 尚子
   所属
食健康科学部 健康デザイン学科
 
女性健康科学研究所 所属教員
   職種
准教授
言語種別 英語
発行・発表の年月 2000/02
形態種別 学術雑誌
査読 査読あり
標題 Lack of effect of soy isoflavone on thyroid hyperplasia in rats receiving an iodine-deficient diet.
執筆形態 共著
掲載誌名 Jpn.J.Cancer Res.92(2)
掲載区分国内
巻・号・頁 pp.103-108
著者・共著者 ◎Son.H.Y.,A.Nishikawa,T.Ikeda,T.Imazawa,S.Kimura,M.Hirose
概要 We have reported a dramatic synergism between soy intake and iodine deficiency regarding induction of thyroid hyperplasia in rats. Because isoflavones are active constituents of soybeans, in the present study, their possible contribution was examined. Female F344 rats were divided into 8 groups, exposed to diet containing a 0.2% soy isoflavone mixture (SI), 0.2% SI + iodine deficiency (ID), 0.04% SI, 0.04% SI + ID, 20% defatted soybean (DS) alone, 20% DS + ID, ID alone or basal diet alone for 5 weeks. These results thus suggest that isoflavones may not be involved in the mechanisms underlying the synergistic goitrogenic effect of soybean with iodine deficiency.