イケダ タカコ    IKEDA Takako
   池田 尚子
   所属
食健康科学部 健康デザイン学科
 
女性健康科学研究所 所属教員
   職種
准教授
言語種別 英語
発行・発表の年月 2001/04
形態種別 学術雑誌
査読 査読あり
標題 Synergistic effects of high-dose soybean intake with iodine deficiency, but not sulfadimethoxine or phenobarbital, on rat thyroid proliferation
執筆形態 共著
掲載誌名 Jpn.J.Cancer Res.92(4)
掲載区分国内
巻・号・頁 pp.390-395
著者・共著者 ◎T.Ikeda,A.Nishikawa,Son.H.Y.,H.Nakamura,M.Miyauchi,T.Imazawa,S.Kimura,M.Hirose
概要 The specificity and dose dependence of the synergistic effects of soybean intake with iodine deficiency on the induction of thyroid proliferation were investigated in female F344 rats. In the first experiment, rats were divided into 6 groups, each consisting of 5 animals, and fed a basal diet containing 20% gluten, an iodine-deficient basal diet alone or an iodine-deficient diet containing 0.2%, 1.0%, 5.0% or 25% defatted soybean for 5 weeks. Our results clearly indicate that soybean feeding does not synergistically enhance the effects of SDM or PB on the rat thyroid. Thus it can be concluded that soybean intake specifically interacts with iodine deficiency in induction of thyroid proliferative lesions in rats, only at high doses.