コニシ　カナエ    KONISHI Kanae
   小西　香苗
   所属
食健康科学部 管理栄養学科
 
女性健康科学研究所 所属教員
 
生活機構研究科 生活科学研究専攻
   職種
准教授
言語種別 英語
発行・発表の年月 2018/03
形態種別 学術雑誌
査読 査読あり
標題 Effects of low-level prenatal exposure to dioxins on cognitive development in Japanese children at 42months.
執筆形態 共著
掲載誌名 Sci Total Environ.
掲載区分国外
巻・号・頁 15(618),pp.1423-1430
著者・共著者 Ikeno T, Miyashita C, Nakajima S, Kobayashi S, Yamazaki K, Saijo Y, Kita T, Sasaki S, Konishi K, Kajiwara J, Hori T, Kishi R.
概要 Objective: To examine whether the effects of DLCs on cognitive development remains at 42months.
Methods: In this prospective cohort study conducted in Sapporo, Japan, pregnant mothers' blood was analyzed for the congener level of DLCs. The Kaufman Assessment of Battery for Children (K-ABC) was used to test their children's cognitive development at 42months.
Results: Seven isomers, total PCDF, and TEQ-PCDD, PCDF, PCDD/DFs levels were positively associated with the achievement score (AS) of K-ABC. However, total non-ortho PCBs were negatively associated with the Mental Processing Composite Score (MPCS) of K-ABC in males.
Conclusions: This study suggests that the negative effects of prenatal DLC exposure on children's cognitive development at 6months were not observed in children aged 42months.
DOI https://doi.org/10.1016/j.scitotenv.2017.09.267