コニシ カナエ KONISHI Kanae
|標題||Effects of low-level prenatal exposure to dioxins on cognitive development in Japanese children at 42months.|
|掲載誌名||Sci Total Environ.|
|著者・共著者||Ikeno T, Miyashita C, Nakajima S, Kobayashi S, Yamazaki K, Saijo Y, Kita T, Sasaki S, Konishi K, Kajiwara J, Hori T, Kishi R.|
|概要||Objective: To examine whether the effects of DLCs on cognitive development remains at 42months.
Methods: In this prospective cohort study conducted in Sapporo, Japan, pregnant mothers' blood was analyzed for the congener level of DLCs. The Kaufman Assessment of Battery for Children (K-ABC) was used to test their children's cognitive development at 42months.
Results: Seven isomers, total PCDF, and TEQ-PCDD, PCDF, PCDD/DFs levels were positively associated with the achievement score (AS) of K-ABC. However, total non-ortho PCBs were negatively associated with the Mental Processing Composite Score (MPCS) of K-ABC in males.
Conclusions: This study suggests that the negative effects of prenatal DLC exposure on children's cognitive development at 6months were not observed in children aged 42months.