ウメガキ ケイゾウ    UMEGAKI Keizo
   梅垣 敬三
   所属
食健康科学部 食安全マネジメント学科
 
生活機構研究科 生活科学研究専攻
 
研究支援機器センター 所属教員
 
生活機構研究科 生活機構学専攻
   職種
教授
言語種別 英語
発行・発表の年月 1986
形態種別 学術雑誌
査読 査読あり
標題 Defects of thrombin-induced protein phosphorylation in platelets from stroke-prone spontaneously hypertensive rats.
執筆形態 共著
掲載誌名 FEBS Lett
掲載区分国外
巻・号・頁 196(1),pp.139-144
著者・共著者 ◎Umegaki, K., M. Ikeda, K. Nakamura, and T. Tomita
概要 Aggregation and secretion of washed platelets from stroke-prone spontaneously hypertensive rats (SHRSP) were greatly reduced by the development of the hypertension compared with those of platelets from age-matched normotensive Wistar-Kyoto rats (WKY). The results suggest that protein kinase C activity and its substrate were normally present in SHRSP platelets and that defects in the receptor-mediated activation of protein kinase C. This defective protein phosphorylation may be an underlying mechanism for the dysfunction of SHRSP platelets.