ウメガキ ケイゾウ    UMEGAKI Keizo
   梅垣 敬三
   所属
生活科学部 食安全マネジメント学科
 
生活機構研究科 生活科学研究専攻
   職種
教授
言語種別 英語
発行・発表の年月 2011
形態種別 学術雑誌
査読 査読あり
標題 Ascorbic acid levels and neutrophil superoxide production in blood of pre-, early and late hypertensive stroke-prone spontaneously hypertensive rats.
執筆形態 共著
掲載誌名 Clin Exp Hypertens
掲載区分国外
巻・号・頁 33(6),pp.397-403
著者・共著者 Sato, Y., Ikeda, M., Ito, T., Tomita, T., Yokotani, K., Murata, M., Umegaki K
概要 We compared ascorbic acid (AA) levels in the blood and TPA- and fMLP-stimulated superoxide (O(2)(*-)) production in neutrophils of pre-, early, and late hypertensive stroke-prone spontaneously hypertensive rats (SHRSP) with those of age-matched Wistar Kyoto rats (WKY), or two other normotensive strains of rats. The data suggest that bi-phasic AA levels in the blood of SHRSP comprise congenitally high levels and a decrease after persistent hypertension due to enhanced O(2)(*-) production and a decrease in de novo AA synthesis through GLO.