ウメガキ ケイゾウ    UMEGAKI Keizo
   梅垣 敬三
   所属
生活科学部 食安全マネジメント学科
 
生活機構研究科 生活科学研究専攻
   職種
教授
言語種別 英語
発行・発表の年月 2002
形態種別 学術雑誌
査読 査読あり
標題 Physical exercise induces oxidation of plasma protein thiols to cysteine mixed disulfides in humans.
執筆形態 共著
掲載誌名 J Health Science
掲載区分国外
巻・号・頁 48,pp.399-403
著者・共著者 Inayama T, Kashiba M, Oka J, Higuchi M, Umegaki K, Saito M, Yamamoto Y, Matsuda M
概要 We observed an increase in protein cysteine mixed disulfides (p-S-Cys) after running, as evidenced by reducing plasma proteins with dithiothreitol to detect the increase of cysteine, along with the concomitant decrease in p-SHs in plasma. However, plasma protein-bound glutathione (GSH) and S-nitroso-protein were undetectable before and after exercise. Test tube experiments suggest that p-S-Cys are probably formed by the hydrolysis of protein GSH mixed disulfides by γ-glutamyltranspeptidase and peptidase, and/or by the oxidative addition of p-SHs to cystine.