タカオ テツヤ    TAKAO Tetsuya
   高尾 哲也
   所属
食健康科学部 食安全マネジメント学科
 
生活機構研究科 生活科学研究専攻
 
国際文化研究所 所属教員
 
生活機構研究科 生活機構学専攻
 
女性健康科学研究所 所属教員
 
現代ビジネス研究所 所属教員
   職種
教授
発表年月日 2022/12/09
発表テーマ Changes in response and saliva-related gene expression into amino acid stimulation in cell line A253.
発表学会名 22nd IUNS-International Congress of Nutrition
学会区分 国際学会
発表形式 ポスター
単独共同区分 共同
開催地名 Tokyo
開催期間 2022/12/06～2022/12/11
発表者・共同発表者 Nanami Sakakibara, Mieko Aoki, Kyoichi Takao, Tetsuya Takao
概要 Decreased saliva secretion is thought to be one of the causes of food intake reduction, malnutrition and decline in their QOL. Increased salivation by salivary gland stimulation have the potential to improve QOL. Cell line A253 from human salivary gland tumor was used to attempted to find metrics for salivary gland stimulation. In this study, we examined the responsiveness to amino acids and the expression of saliva-related genes using the A253. Among 20 amino acids, A253 responded to 14 amino acids. The expression level of AMYLA was changed by the stimulation with alanine, arginine, lysine and phenylalanine. Similarly, expression level of MUC7 was changed by the stimulation with alanine, arginine and lysine and ANO1 was changed with only alanine and arginine. From above results, it is speculated that changes in the expression of these genes may be indicators of salivary gland stimulation. This research was supported by a Grant-in-Aid from the Showa Women's University.