ヤマナカ ケンタロウ    YAMANAKA Kentarou
   山中 健太郎
   所属
生活科学部 健康デザイン学科
 
生活機構研究科 生活科学研究専攻
 
生活機構研究科 生活機構学専攻
 
女性健康科学研究所 所属教員
   職種
教授
言語種別 英語
発行・発表の年月 2013/11
形態種別 学術雑誌
査読 査読あり
標題 Long-latency TMS-evoked potentials during motor execution and inhibition.
執筆形態 共著
掲載誌名 Frontiers in Human Neuroscience
掲載区分国外
出版社・発行元 Frontiers Media S.A
巻・号・頁 7(751),pp.1-11
著者・共著者 Yamanaka K. Kadota H. Nozaki D.
概要 Transcranial magnetic stimulation (TMS) has often been used in conjunction with electroen-cephalography (EEG), which is effective for the direct demonstration of cortical reactivity and corticocortical connectivity during cognitive tasks through the spatio-temporal pattern of long-latency TMS-evoked potentials(TEPs). However, it remains unclear what pattern is associated with the inhibition of a planned motor response. Therefore, we performed TMS-EEG recording during a go/stop task, in which participants were instructed to click a computer mouse with a right index finger when an indicator that was moving with a constant velocity reached a target (go trial) or to avoid the click when the indicator randomly stopped just before it reached the target (stop trial). Single-pulse TMS to the left(contralateral) or right (ipsilateral) motor cortex was applied 500 ms before or just at the target time.TEPs related to motor execution and inhibition were obtained by subtractions between averaged EEG waveforms with and without TMS. As a result, in TEPs induced by both contralateral and ipsilateral TMS, small oscillations were followed by a prominent negative deflection around the TMS site peaking at approximately 100 ms post-TMS (N100), and a less pronounced later positive component (LPC) over the broad areas that was centered at the midline-central site in both go and stop trials. However, compared to the pattern in go and stop trials with TMS at 500 ms before the target time, N100 and LPC were differently modulated in the go and stop trials with TMS just at the target time. The amplitudes of both N100 and LPC decreased in go trials, while the amplitude of LPC decreased and the latency of LPC was delayed in both go and stop trials. These results suggested that TMS-induced neuronal reactions in the motor cortex and subsequent their propagation to surrounding cortical areas might change functionally according to task demand when executing and inhibiting a motor response.
DOI 10.3389/fnhum.2013.007512013