ムラヤマ ノリオ    Murayama Norio
   村山 憲男
   所属
人間社会学部 心理学科
 
生活機構研究科 心理学専攻
 
生活心理研究所 所属教員
 
生活機構研究科 生活機構学専攻
   職種
准教授
言語種別 英語
発行・発表の年月 2015/01
形態種別 学術雑誌
査読 査読あり
標題 Cognitive dysfunction in patients with very mild Alzheimer's disease and amnestic mild cognitive impairment showing hemispheric asymmetries of hypometabolism on 18F-FDG PET
執筆形態 共著
掲載誌名 International Journal of Geriatric Psychiatry
掲載区分国外
巻・号・頁 31,pp.41-48
著者・共著者 ◎Norio MURAYAMA, Kazumi OTA, Koji KASANUKI, DAIZO Kondo, Hiroshige FUJISHIRO, Yuko FUKASE, Hirokuni TAGAYA, Eizo ISEKI
概要 Objective: We investigated cognitive dysfunction in patients with Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI) who present hemispheric asymmetries of cerebral metabolic rate of glucose (CMRglc) decrease on (18) F-fluorodeoxyglucose positron emission tomography.
Methods: Based on the hemispheric asymmetries of CMRglc decrease in the posterior cingulate cortex, precuneus, and parietotemporal cortex, the patients were divided into three groups (a left-dominant hypometabolism group, a right-dominant hypometabolism group, and a non-dominant hypometabolism group). CMRglc decrease in the whole brain was controlled among the three groups. All the patients underwent mini-mental state examination (MMSE), Wechsler Memory Scale-Revised (WMS-R), and Wechsler Adult Intelligent Scale-Third (WAIS-III).
Results: There were no significant differences in MMSE and WAIS-III scores among the three groups. In WMS-R, the results indicated that the left-dominant group demonstrated significantly lower scores in verbal memory than the other two groups. Furthermore, the left-dominant group had a greater tendency to be diagnosed with AD rather than aMCI.
Conclusions: Patients with AD and aMCI showing left-dominant hypometabolism tend to show severer impairment in verbal memory function and to be diagnosed with AD dementia.