ムラヤマ ノリオ    Murayama Norio
   村山 憲男
   所属
人間社会学部 心理学科
 
生活機構研究科 心理学専攻
 
生活心理研究所 所属教員
 
生活機構研究科 生活機構学専攻
   職種
准教授
言語種別 英語
発行・発表の年月 2013/11
形態種別 学術雑誌
査読 査読あり
標題 Higher cortisol levels at diurnal trough predict greater attentional bias towards threat in healthy young adults
執筆形態 共著
掲載誌名 Journal of Affective Disorders
掲載区分国外
巻・号・頁 151,pp.775-779
著者・共著者 Yuko HAKAMATA, Shuhei IZAWA, Eisuke SATO, Shotaro KOMI, Norio MURAYAMA, Yoshiya MORIGUCHI, Takashi HANAKAWA, Yusuke INOUE, Hirokuni TAGAYA
概要 Background: Attentional bias (AB), selective information processing towards threat, can exacerbate anxiety and depression. Despite growing interest, physiological determinants of AB are yet to be understood. We examined whether stress hormone cortisol and its diurnal variation pattern contribute to AB.
Methods: Eighty-seven healthy young adults underwent assessments for AB, anxious personality traits, depressive symptoms, and attentional function. Salivary cortisol was collected at three time points daily (at awakening, 30 min after awakening, and bedtime) for 2 consecutive days. We performed: (1) multiple regression analysis to examine the relationships between AB and the other measures and (2) analysis of variance (ANOVA) between groups with different cortisol variation patterns for the other measures.
Results: Multiple regression analysis revealed that higher cortisol levels at bedtime (p<0.001), an anxious personality trait (p=0.011), and years of education (p=0.036) were included in the optimal model to predict AB (adjusted R(2)=0.234, p<0.001). ANOVA further demonstrated significant mean differences in AB and depressive symptoms; individuals with blunted cortisol variation exhibited significantly greater AB and depression than those with moderate variation (p=0.037 and p=0.009, respectively).
Limitations: Neuropsychological assessment focused on attention and cortisol measurement at three time points daily.
Conclusions: We showed that higher cortisol levels at bedtime and blunted cortisol variation are associated with greater AB. Individuals who have higher cortisol levels at diurnal trough might be at risk of clinical anxiety or depression but could also derive more benefits from the attentional-bias-modification program.