ムラヤマ ノリオ    Murayama Norio
   村山 憲男
   所属
人間社会学部 心理学科
 
生活機構研究科 心理学専攻
 
生活心理研究所 所属教員
 
生活機構研究科 生活機構学専攻
   職種
准教授
言語種別 英語
発行・発表の年月 2010/04
形態種別 学術雑誌
査読 査読あり
標題 Construction of a (18)F-FDG PET normative database of Japanese healthy elderly subjects and its application to demented and mild cognitive impairment patients
執筆形態 共著
掲載誌名 International Journal of Geriatric Psychiatry
掲載区分国外
巻・号・頁 25,pp.352-361
著者・共著者 Eizo ISEKI, Norio MURAYAMA, Ryoko YAMAMOTO, Masaru SUZUKI, Masato KAWANO, Shuya MIKI, Kiyoshi SATO
概要 Objective: To construct a (18)F-FDG PET normative database of Japanese healthy elderly subjects and to apply it to demented and mild cognitive impairment (MCI) patients.
Methods: Seventy-seven Japanese normal volunteers from 41 to 84 years of age (36 males and 41 females) who underwent clinical, neuropsychological, and MRI examinations were selected. In these subjects, (18)F-FDG PET/CT scans were performed, (18)F-FDG PET images were analyzed using the 3D-SSP program, and a normative database for cerebral glucose metabolism was constructed. Then, (18)F-FDG PET images from 14 demented and MCI patients were evaluated based on the normative database.
Results: The 77 healthy elderly subjects were divided into three groups according to their age. In these subjects, the difference in glucose metabolism between males and females was minimal in contrast, glucose metabolism showed a weak reciprocal correlation with aging in several cerebral regions. The 3D-SSP images of 14 demented and MCI patients based on the age-matched (18)F-FDG PET normative database showed decreased patterns of glucose metabolism similar to those of previous studies on dementia diseases and MCI.
Conclusions: An age-matched normative database can be applied to the evaluation of single subjects, and the application of a mixed database of males and females is viable. Normative databases are useful for detecting dementia diseases and their MCI.