ムラヤマ ノリオ    Murayama Norio
   村山 憲男
   所属
人間社会学部 心理学科
 
生活機構研究科 心理学専攻
 
生活心理研究所 所属教員
 
生活機構研究科 生活機構学専攻
   職種
准教授
言語種別 英語
発行・発表の年月 2008/03
形態種別 学術雑誌
査読 査読あり
標題 Neuropathological investigation of regions responsible for semantic aphasia in frontotemporal lobar degeneration
執筆形態 共著
掲載誌名 Dementia and Geriatric Cognitive Disorders
掲載区分国外
巻・号・頁 27,pp.214-223
著者・共著者 Ryoko YAMAMOTO, Eizo ISEKI, Shinji HIGASHI, Norio MURAYAMA, Michiko MINEGISHI, Kiyoshi SATO, Hiroaki HINO, Koshiro FUJISAWA, Kenji KOSAKA, Takashi TOGO, Omi KATSUSE, Hirotake UCHIKADO, Yoshiko FURUKAWA, Mari YOSHIDA, Yoshio HASHIZUME, Heii ARAI
概要 Background/aims: Semantic dementia is a subtype of frontotemporal lobar degeneration, of which an initial symptom is semantic aphasia. Semantic dementia pathologically corresponds to atypical Pick's disease (aPiD), showing ubiq- uitin-positive inclusions similar to those in dementia with motor neuron disease (D-MND). Previous studies have not clarified the regions responsible for semantic aphasia in aPiD, and there have been no reported neuropathological studies concerning its pathomechanism.
Methods: We neuropathologically investigated aPiD and D-MND cases with and without semantic aphasia.
Results: We determined that the regions involved in the early stage of the disease course of semantic dementia were more restricted to the anterior and inferior portion of the temporal lobe on the side of the dominant hemisphere.
Conclusion: Degeneration of the temporal pole is most likely to participate in the pathomechanism of SA in semantic dementia.