ムラヤマ ノリオ    Murayama Norio
   村山 憲男
   所属
人間社会学部 心理学科
 
生活機構研究科 心理学専攻
 
生活心理研究所 所属教員
   職種
准教授
言語種別 英語
発行・発表の年月 2007/03
形態種別 学術雑誌
査読 査読あり
標題 Correlation in Lewy pathology between the claustrum and visual areas in brains of dementia with Lewy bodies
執筆形態 共著
掲載誌名 Neuroscience Letters
掲載区分国外
巻・号・頁 415,pp.219-224
著者・共著者 Ryoko YAMAMOTO, Eizo ISEKI, Norio MURAYAMA, Michiko MINEGISHI, Wami MARUI, Takashi TOGO, Omi KATSUSE, Kenji KOSAKA, Masanori KATO, Takeshi IWATSUBO, Heii ARAI
概要 We investigated Lewy pathologies in the claustrum and the related cerebral cortices and subcortical nuclei of dementia with Lewy bodies (DLB) brains using alpha-synuclein-immunohistochemistry to clarify the relationship between Lewy pathology in the claustrum and visual misidentification of DLB patients. The claustrum is known to have strong reciprocal connections with the visual areas. Consequently, the claustrum demonstrated many Lewy bodies (LB) and LB-related neurites. The insular and inferior temporal cortices, amygdala, BA 18, 19, transentohrinal and cingulate cortices showed stronger or similar Lewy pathology as compared with the claustrum, while BA 17, precentral, postcentral and transverse temporal cortices showed weaker Lewy pathology. Comparing the correlation coefficient of Lewy pathology between the clausturm and other regions, BA 18 and 19 as well as the insular and transentorhinal cortices demonstrated a higher correlation coefficient. These findings suggest that Lewy pathology in the claustrum is more closely associated with that in visual areas than in auditory, somatosensory or motor areas, and that dysfunction of the visuo-claustral pathway participates in visual misidentification in addition to the visuo-amygdaloid pathway. The paralimbic cortices including the insular and transentorhinal cortices may connect visual areas with limbic areas by relay of the visuo-claustral or visuo-amygdaloid pathway.