ワタナベ ナカミチ    WATANABE Nakamichi
   渡辺 睦行
   所属
食健康科学部 健康デザイン学科
 
生活機構研究科 生活科学研究専攻
 
女性健康科学研究所 所属教員
   職種
准教授
言語種別 英語
発行・発表の年月 2014
形態種別 学術雑誌
査読 査読あり
標題 Nutriglycomics in Mice Fed High-Fat or Low-Protein Diets
執筆形態 共著
掲載誌名 Austin Journal of Nutrition & Metabolism
巻・号・頁 1(2)
概要 While glycomics describesthe global analysis of carbohydrateswithin a biological system, the neologism, nutriglycomics,defines the combination of nutrition with glycomics.Generally, the glycanprofile of an organism can beaffectedby environmental changes. However, there have been no studies that have investigated the effects of dietary composition on the glycan profiles of blood serum. The aim of this study was to explorethe effects of dietary extremes, specifically high-fat and low-protein diets, on serum glycanprofiles in mice.To this end, 5-week-old, male, C57BL/6J mice were divided into 3 groups and were fed respective experimental diets: control, lowprotein, and highfat. After 3 weeks of feeding on the trial diets,47different glycans were detected in blood serum. The glycan profile of the high-fat diet group was notsignificantly different from that of the control group. In contrast, the low-protein diet group had a significant increase in5 types and a decrease in 13 types of glycans compared to the control group.These results validate our hypothesis that dietary composition, in this case, a low-protein diet, can affect serum glycan profiles in mice.