ワタナベ ナカミチ
WATANABE Nakamichi
渡辺 睦行 所属
食健康科学部 健康デザイン学科
女性健康科学研究所 所属教員
生活機構研究科 生活科学研究専攻
生活機構研究科 生活機構学専攻
職種
教授
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言語種別 | 英語 |
発行・発表の年月 | 2019 |
形態種別 | 学術雑誌 |
査読 | 査読あり |
標題 | Expression of genes related to glycolysis in the liver and skeletal muscle of rats after citric acid administration |
執筆形態 | 共著 |
掲載誌名 | Food and Nutrition Sciences |
掲載区分 | 国外 |
著者・共著者 | Yurie Hara, Nakamichi Watanabe |
概要 | Citric acid is known to alleviate physical fatigue and improve athletic performance; however, the underlying mechanism is unknown. Therefore, we aimed to investigate the effect of citric acid administration on the expression of key glycolysis-related genes in the liver and skeletal muscle of rats. Eight-week-old male Sprague Dawley rats were divided into two groups-control and citric acid groups. The rats were fasted overnight, after which distilled water or citric acid solution was administered intragastrically; after 150 min, the rats were sacrificed, and the liver and skeletal muscle were collected. In the skeletal muscle, namely soleus and gastrocnemius muscles, the phosphofructokinase and pyruvate kinase gene expression were significantly decreased by citric acid administration. In contrast, the glucokinase and pyruvate kinase gene expression in the liver was significantly increased. These results suggest that exogenous dietary citric acid suppresses glycolysis in the skeletal muscle at the transcription level. |