ワタナベ ナカミチ    WATANABE Nakamichi
   渡辺 睦行
   所属
食健康科学部 健康デザイン学科
 
生活機構研究科 生活科学研究専攻
 
女性健康科学研究所 所属教員
   職種
准教授
言語種別 英語
発行・発表の年月 2019
形態種別 学術雑誌
査読 査読あり
標題 Dietary intake of green nut oil or DHA ameliorates DHA distribution in the brain of a mouse model
of dementia accompanied by memory recovery
執筆形態 共著
掲載誌名 Nutrients
掲載区分国外
巻・号・頁 11,pp.2371
著者・共著者 Emiko Takeyama, Ariful Islam, Nakamichi Watanabe, Hiroe Tsubaki,
Masako Fukushima, Md. Al Mamun, Shumpei Sato, Tomohito Sato, Fumihiro Eto,
Ikuko Yao, Takashi K. Ito, Makoto Horikawa, Mitsutoshi Setou
概要 Oil extracted from the seeds of Plukenetia volubilis (green nut oil; GNO) is also expected to have DHA like effects as it contains approximately 50% α-linolenic acid, a precursor of DHA. Despite this, changes in the spatial distribution of DHA in the brain of animals with dementia following GNO or DHA supplementation remain unexplored. In this study, desorption electrospray ionization imaging mass spectrometry (DESI-IMS) was applied to observe the effects of GNO or DHA supplementation upon the distribution of DHA in the brain of male senescence-accelerated mouse-prone 8 (SAMP8) mice, a mouse model of dementia. DESI-IMS revealed that brain DHA distribution increased 1.85-fold and 3.67-fold in GNO-fed and DHA-fed SAMP8 mice, respectively, compared to corn oil-fed SAMP8 mice. Memory efficiency in SAMP8 mice was also improved by GNO or DHA supplementation. In summary, this study suggests the possibility of GNO or DHA supplementation for the prevention of dementia.