ワタナベ ナカミチ
WATANABE Nakamichi
渡辺 睦行 所属
食健康科学部 健康デザイン学科
女性健康科学研究所 所属教員
生活機構研究科 生活科学研究専攻
生活機構研究科 生活機構学専攻
職種
教授
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言語種別 | 英語 |
発行・発表の年月 | 2022 |
形態種別 | 学術雑誌 |
査読 | 査読あり |
標題 | Stress upregulates 2-arachidonoylglycerol levels in the hypothalamus, midbrain, and hindbrain, and it is sustained by green nut oil supplementation in SAMP8 mice revealed by DESI-MSI |
執筆形態 | 共著 |
掲載誌名 | Biochemical and Biophysical Research Communications |
掲載区分 | 国外 |
巻・号・頁 | 609,pp.9-14 |
著者・共著者 | Ariful Islam, Emiko Takeyama, Mahamodun Nabi, Qing Zhai, Masako Fukushima, Nakamichi Watanabe, Al Mamun, Kenji Kikushima, Tomoaki Kahyo, Mitsutoshi Setou |
概要 | Green nut oil (GNO) supplementation also increased brain 2AG in SAMP8 mice without stress load. Additionally, GNO supplementation sustained the increased brain endocannabinoid 2-arachidonoylglycerol (2AG) levels in stress given SAMP8 mice after eighteen days of removing stress load. Among all brain regions, a relatively higher accumulation of 2AG was noted in the hypothalamus, midbrain, and hindbrain of GNO-fed SAMP8. Our data explored the potentiality of GNO supplementation to improve brain 2AG levels which might be used to treat anxiety and depressive behaviors. |