ワタナベ ナカミチ    WATANABE Nakamichi
   渡辺 睦行
   所属
食健康科学部 健康デザイン学科
 
女性健康科学研究所 所属教員
 
生活機構研究科 生活科学研究専攻
 
生活機構研究科 生活機構学専攻
   職種
教授
言語種別 英語
発行・発表の年月 2022
形態種別 学術雑誌
査読 査読あり
標題 Stress upregulates 2-arachidonoylglycerol levels in the hypothalamus, midbrain, and hindbrain, and it is sustained by green nut oil supplementation in SAMP8 mice revealed by DESI-MSI
執筆形態 共著
掲載誌名 Biochemical and Biophysical Research Communications
掲載区分国外
巻・号・頁 609,pp.9-14
著者・共著者 Ariful Islam, Emiko Takeyama, Mahamodun Nabi, Qing Zhai, Masako Fukushima, Nakamichi Watanabe, Al Mamun, Kenji Kikushima, Tomoaki Kahyo, Mitsutoshi Setou
概要 Green nut oil (GNO) supplementation also increased brain 2AG in SAMP8 mice without stress load. Additionally, GNO supplementation sustained the increased brain endocannabinoid 2-arachidonoylglycerol (2AG) levels in stress given SAMP8 mice after eighteen days of removing stress load. Among all brain regions, a relatively higher accumulation of 2AG was noted in the hypothalamus, midbrain, and hindbrain of GNO-fed SAMP8. Our data explored the potentiality of GNO supplementation to improve brain 2AG levels which might be used to treat anxiety and depressive behaviors.