シミズ フミコ    SHIMIZU Fumiko
   清水 史子
   所属
生活科学部 管理栄養学科
 
女性健康科学研究所 所属教員
 
生活機構研究科 生活科学研究専攻
   職種
准教授
言語種別 英語
発行・発表の年月 2018/07
形態種別 学術雑誌
査読 査読あり
標題 Plasma Levels of Tryptophan Metabolites in Healty Young and Old Men and Women, and Patients of Type 2 iabetes Mellitus(T2DM)
執筆形態 共著
掲載誌名 Obesity:Open access
掲載区分国外
巻・号・頁 4(2),pp.1-9
著者・共著者 Shimizu F, Ishii Y, Ogawa M, Takao T, Matsuoka K, Kato K, and Takada A
概要 Plasma levels of tryptophan (TRP) metabolites have not been measured extensively in patients of type 2 diabetes mellitus (T2DM).
Methods: Body mass index (BMI) and plasma levels of various factors such as glucose, lipids and TRP metabolites have been measured in healthy young and old men and women, and patients of T2DM by using the ultrahigh speed liquid chromatography-mass spectroscopy (Shimadzu Corporation).
Results: There are age and gender differences in TRP metabolism. The plasma levels of 5-hydroxytryptophan (5-HTRP), 5-hydroxyindoleacetic acid(5-HIAA), kynurenic acid (KNA), 3-hydroxykynurenine (3-HKN), and 3-hydroxyanthranilic acid (3-HAA) were higher in patients of old men of T2DM than healthy old men. Since 5HTRP and 5-HIAA belong to the serotonin pathway, and KNA, 3-HKN, and 3-HAA belong to the KN pathway of TRP metabolism, these pathways were activated more in the patients of T2DM. Since plasma levels of Indole-3-acetic acid were not elevated in T2DM, that pathway was not activated more in T2DM. Although the serotonin pathway was activated more in the patients of T2DM, serotonin (5-HT;5 hydoroxytyptamine) levels were not increased compared with those in T2DM patients, which may mean that 5-HT was quickly metabolized to 5-HIAA in the patients of T2DM.