シミズ フミコ    SHIMIZU Fumiko
   清水 史子
   所属
食健康科学部 管理栄養学科
 
女性健康科学研究所 所属教員
 
生活機構研究科 生活科学研究専攻
   職種
准教授
言語種別 英語
発行・発表の年月 2020
形態種別 学術雑誌
査読 査読あり
標題 Significance of Trans Fatty Acids and Omega-3 Fatty Acids in Japanese Men with Coronary Heart Disease
執筆形態 共著
掲載誌名 New Insights Into Metabolic Syndrome
掲載区分国外
著者・共著者 Shinji Koba, Tetsuya Takao, Fumiko Shimizu, Mutsumi Ogawa, Yuuya Yokota, Fumiyoshi Tsunoda, Ken Arai, Toshiro Shinke and Akikazu Takada
概要 Trans fatty acids are found naturally in ruminant foods by biohydrogenation in ruminant animals or industrially produced oils by partial hydrogenation of vegetable or fish oils.
The intake of TFA mainly IP-TFA is associated with an elevated risk of coronary heart disease, while some prospective cohort studies showed that R-TFA were associated with a lower risk for sudden cardiac death. Our case-control study showed that trans-C18:2 isomers were significantly higher, and palmitelaidic acid levels were lower in patients with acute coronary syndrome (ACS) compared with healthy men. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have different effects on cardiometabolic risk factors. Delta-5 desaturase (D5D) is a key enzyme in the conversion of linoleic acid and alpha-linoleneic acid to arachidonic acid (AA) and EPA, respectively. Previous studies reported that low D5D estimated from the ratio of AA to dihomo-gamma linolenic acid predicts the incident cardiovascular disease. In our cross-sectional study with 436 men with ACS, various atherogenic lipid markers such as small dense LDL cholesterol and malondialdehyde-modified LDL were significantly inversely associated with D5D activity. We found that the EPA/AA may be a superior risk marker than DHA/AA in terms of correlation with atherogenic lipid profiles.