シミズ フミコ SHIMIZU Fumiko
|Significance of Trans Fatty Acids and Omega-3 Fatty Acids in Japanese Men with Coronary Heart Disease
|New Insights Into Metabolic Syndrome
|Shinji Koba, Tetsuya Takao, Fumiko Shimizu, Mutsumi Ogawa, Yuuya Yokota, Fumiyoshi Tsunoda, Ken Arai, Toshiro Shinke and Akikazu Takada
|Trans fatty acids are found naturally in ruminant foods by biohydrogenation in ruminant animals or industrially produced oils by partial hydrogenation of vegetable or fish oils.
The intake of TFA mainly IP-TFA is associated with an elevated risk of coronary heart disease, while some prospective cohort studies showed that R-TFA were associated with a lower risk for sudden cardiac death. Our case-control study showed that trans-C18:2 isomers were significantly higher, and palmitelaidic acid levels were lower in patients with acute coronary syndrome (ACS) compared with healthy men. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have different effects on cardiometabolic risk factors. Delta-5 desaturase (D5D) is a key enzyme in the conversion of linoleic acid and alpha-linoleneic acid to arachidonic acid (AA) and EPA, respectively. Previous studies reported that low D5D estimated from the ratio of AA to dihomo-gamma linolenic acid predicts the incident cardiovascular disease. In our cross-sectional study with 436 men with ACS, various atherogenic lipid markers such as small dense LDL cholesterol and malondialdehyde-modified LDL were significantly inversely associated with D5D activity. We found that the EPA/AA may be a superior risk marker than DHA/AA in terms of correlation with atherogenic lipid profiles.