イケダ タカコ    IKEDA Takako
   池田 尚子
   所属
食健康科学部 健康デザイン学科
 
女性健康科学研究所 所属教員
   職種
准教授
言語種別 英語
発行・発表の年月 2000/09
形態種別 学術雑誌
査読 査読あり
標題 Lack of Modifying effects of environmental estrogenic compounds on the development of thyroid proliferative lesions in male rats
執筆形態 共著
掲載誌名 Jpn.J.Cancer Res.91
掲載区分国内
巻・号・頁 pp.899-905
著者・共著者 ◎Son.H.Y.,A.Nishikawa,T.Ikeda,H.Nakamura,M.Miyauchi,T.Imazawa,F.Furukawa,M.Hirose
概要 The modifying effects of various environmental estrogenic compounds on thyroid carcinogenesis were investigated in a rodent two-stage carcinogenesis model. The compounds examined were a soy isoflavone mixture (SI) and genistein (GEN) as phytoestrogens, nonylphenol (NP) as a xenoestrogen, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) as a thyroid carcinogen and sulfadimethoxine (SDM) as a known thyroid tumor promoter. Our results thus indicate that the weakly estrogenic compounds GEN, SI and NP and the environmental rat thyroid carcinogen MX do not exert any modifying effects on thyroid carcinogenesis in rats under the present experimental conditions.