イケダ タカコ
IKEDA Takako
池田 尚子 所属
食健康科学部 健康デザイン学科
女性健康科学研究所 所属教員
職種
准教授
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言語種別 | 英語 |
発行・発表の年月 | 2000/07 |
形態種別 | 学術雑誌 |
査読 | 査読あり |
標題 | Sequential observation of 2,6-dimethylaniline-induced nasal lesions in rat two-stage nasal carcinogenesis model after initiation with N-bis(2-hydroxypropyl) nitrosamine |
執筆形態 | 共著 |
掲載誌名 | J.Vet.Med.Sci.,62(2000) |
掲載区分 | 国内 |
巻・号・頁 | pp.751-756 |
著者・共著者 | ◎T.Koujitani,K.Yasuhara,T.Imazawa,T.Tamura,K.Toyosawa,T.Ikeda,A.Shimada,M.Hirose,K.Mitsumori |
概要 | Male F344 rats received diet containing 3,000 ppm 2,6-dimethylaniline (DMA) after initiation with a single subcutaneous injection of 2,400 mg/kg of N-bis(2-hydroxypropyl)nitrosamine (DHPN), and histological and electron microscopic examinations of the nasal cavity were performed at 4, 13, 26 and 52 weeks to examine sequential changes induced by DMA. These results suggest that Bowman's glands are the target of DMA, giving rise to nasal carcinomas after DHPN-initiation. |