イケダ タカコ    IKEDA Takako
   池田 尚子
   所属
食健康科学部 健康デザイン学科
 
女性健康科学研究所 所属教員
   職種
准教授
言語種別 英語
発行・発表の年月 2000/07
形態種別 学術雑誌
査読 査読あり
標題 Sequential observation of 2,6-dimethylaniline-induced nasal lesions in rat two-stage nasal carcinogenesis model after initiation with N-bis(2-hydroxypropyl) nitrosamine
執筆形態 共著
掲載誌名 J.Vet.Med.Sci.,62(2000)
掲載区分国内
巻・号・頁 pp.751-756
著者・共著者 ◎T.Koujitani,K.Yasuhara,T.Imazawa,T.Tamura,K.Toyosawa,T.Ikeda,A.Shimada,M.Hirose,K.Mitsumori
概要 Male F344 rats received diet containing 3,000 ppm 2,6-dimethylaniline (DMA) after initiation with a single subcutaneous injection of 2,400 mg/kg of N-bis(2-hydroxypropyl)nitrosamine (DHPN), and histological and electron microscopic examinations of the nasal cavity were performed at 4, 13, 26 and 52 weeks to examine sequential changes induced by DMA. These results suggest that Bowman's glands are the target of DMA, giving rise to nasal carcinomas after DHPN-initiation.