イケダ タカコ    IKEDA Takako
   池田 尚子
   所属
食健康科学部 健康デザイン学科
 
女性健康科学研究所 所属教員
   職種
准教授
言語種別 英語
発行・発表の年月 2000/04
形態種別 学術雑誌
査読 査読あり
標題 Dramatic synergism between excess soybean intake and iodine deficiency on the development of rat thyroid hyperplasia
執筆形態 共著
掲載誌名 Carcinogenesis 21(4),(2000)
掲載区分国外
巻・号・頁 pp.707-713
著者・共著者 ◎T.Ikeda,A.Nishikawa,T.Imazawa,S.Kimura,M.Hirose
概要 The effects of defatted soybean and/or iodine-deficient diet feeding were investigated in female F344 rats. Rats were divided into four groups, each consisting of 10 animals, and fed basal AIN-93G diet in which the protein was exchanged for 20% gluten (Group 1), iodine-deficient gluten (Group 2), 20% defatted soybean (Group 3) and iodine-deficient defatted soybean (Group 4). Histologically, marked diffuse follicular hyperplasia of the thyroid was evident in Group 4 rats.Ultrastructurally, severe disorganization and disarrangement of mitochondria were apparent in thyroid follicular cells of Group 4. Our results thus strongly suggest that dietary defatted soybean synergistically stimulates the growth of rat thyroid with iodine deficiency, partly through a pituitary-dependent pathway.