イケダ タカコ
IKEDA Takako
池田 尚子 所属
食健康科学部 健康デザイン学科
女性健康科学研究所 所属教員
職種
准教授
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言語種別 | 英語 |
発行・発表の年月 | 1999/01 |
形態種別 | 学術雑誌 |
査読 | 査読あり |
標題 | Failure of phenethyl isothiocyanate to inhibit hamster tumorigenesis induced by N-nitrosobis(2-oxopropyl)amine when given during the post-initation phase |
執筆形態 | 共著 |
掲載誌名 | Cancer Letters, 141, (1999) |
掲載区分 | 国外 |
巻・号・頁 | pp.109-115 |
著者・共著者 | ◎A. Nishikawa, F. Furukawa, K. Kasahara, Z. Tanakamaru, M. Miyauchi, H. Nakamura, T. Ikeda, T. Imazawa, M. Hirose |
概要 | The chemopreventive influence of phenethyl isothiocyanate (PEITC) during the post-initiation stage was investigated in the N-nitrosobis(2-oxopropyl)amine (BOP)-initiated hamster tumorigenesis model. A total of 120 female 5-week-old hamsters were divided into six groups. Starting 1 week after the second BOP injection, hamsters in groups 1 and 2 were fed diets supplemented with 6 micromol/g and 3 micromol/g of PEITC, respectively, for 51 weeks. Taken together with our previous finding that PEITC dramatically inhibited the initiation phase of BOP-induced pancreatic and lung tumorigenesis in hamsters, it can be concluded that PEITC specifically exerts chemopreventive effects only when given concomitantly with the carcinogen. |