イケダ タカコ    IKEDA Takako
   池田 尚子
   所属
食健康科学部 健康デザイン学科
 
女性健康科学研究所 所属教員
   職種
准教授
言語種別 英語
発行・発表の年月 1999/01
形態種別 学術雑誌
査読 査読あり
標題 Failure of phenethyl isothiocyanate to inhibit hamster tumorigenesis induced by N-nitrosobis(2-oxopropyl)amine when given during the post-initation phase
執筆形態 共著
掲載誌名 Cancer Letters, 141, (1999)
掲載区分国外
巻・号・頁 pp.109-115
著者・共著者 ◎A. Nishikawa, F. Furukawa, K. Kasahara, Z. Tanakamaru, M. Miyauchi, H. Nakamura, T. Ikeda, T. Imazawa, M. Hirose
概要 The chemopreventive influence of phenethyl isothiocyanate (PEITC) during the post-initiation stage was investigated in the N-nitrosobis(2-oxopropyl)amine (BOP)-initiated hamster tumorigenesis model. A total of 120 female 5-week-old hamsters were divided into six groups. Starting 1 week after the second BOP injection, hamsters in groups 1 and 2 were fed diets supplemented with 6 micromol/g and 3 micromol/g of PEITC, respectively, for 51 weeks. Taken together with our previous finding that PEITC dramatically inhibited the initiation phase of BOP-induced pancreatic and lung tumorigenesis in hamsters, it can be concluded that PEITC specifically exerts chemopreventive effects only when given concomitantly with the carcinogen.