イケダ タカコ IKEDA Takako
|Pronounced synergistic promotion of N-Bis(2-hydroxypropyl)Nitrosamine-Initiated thyroid tumorigenesis in rats treated with excess soybean and iodine-deficient diets
|Toxicological sciences 86(2),(2005)
|We have reported that excess soybean treatment and iodine deficiency synergistically interact, resulting in remarkable induction of thyroid hyperplasias in rats. In the present study, modifying effects of excess soybean and iodine-deficient diets were investigated in the post-initiation phase of N-bis(2-hydroxypropyl)nitrosamine [DHPN]-initiated thyroid tumorigenesis in rats. Thus co-exposure to excess soybean and iodine deficiency results in synergistic promotion of DHPN-initiated thyroid tumorigenesis in rats, of which mechanisms appear to primarily involve effects on serum hormone levels.