イケダ タカコ    IKEDA Takako
   池田 尚子
   所属
食健康科学部 健康デザイン学科
 
女性健康科学研究所 所属教員
   職種
准教授
言語種別 英語
発行・発表の年月 2005/05
形態種別 学術雑誌
査読 査読あり
標題 Pronounced synergistic promotion of N-Bis(2-hydroxypropyl)Nitrosamine-Initiated thyroid tumorigenesis in rats treated with excess soybean and iodine-deficient diets
執筆形態 共著
掲載誌名 Toxicological sciences 86(2),(2005)
掲載区分国外
巻・号・頁 pp.258-263
著者・共著者 ◎A.Nishikawa,T.Ikeda,Son.H.Y.,K.Okazaki,T.Imazawa,T.Umemura,S.Kimura,M.Hirose
概要 We have reported that excess soybean treatment and iodine deficiency synergistically interact, resulting in remarkable induction of thyroid hyperplasias in rats. In the present study, modifying effects of excess soybean and iodine-deficient diets were investigated in the post-initiation phase of N-bis(2-hydroxypropyl)nitrosamine [DHPN]-initiated thyroid tumorigenesis in rats. Thus co-exposure to excess soybean and iodine deficiency results in synergistic promotion of DHPN-initiated thyroid tumorigenesis in rats, of which mechanisms appear to primarily involve effects on serum hormone levels.