コンドウ　カズナリ    KONDO KAZUNARI
   近藤 一成
   所属
食健康科学部 食安全マネジメント学科
   職種
教授
言語種別 英語
発行・発表の年月 1999
形態種別 学術雑誌
査読 査読あり
標題 Some Sulfur-Containing Metabolites of Tri- n -butyltin Chloride in Male Rats
執筆形態 共著
掲載誌名 Journal of Agricultural and Food Chemistry
掲載区分国外
巻・号・頁 47,pp.4791-4798
著者・共著者 Suzuki T, Kondo K, Uchiyama M, Murayama M
概要 In an attempt to elucidate metabolic destination of TBTO, sulfur-containing metabolites were investigated in the urine. Tri-n-butyltin chloride (TBTC), tri-n-butyltin oxide (TBTO), and their in vitro metabolites in rat liver microsomal enzyme systems, di-n-butyl(3-hydroxybutyl)tin chloride (T3OH), di-n-butyl(3-oxobutyl)tin chloride (T3CO), dibutyltin dichloride (DBTC), and monobutyltin trichloride (MBTC), were intraperitoneally administered to rats. In particular, administration of T3OH and T3CO gave higher amounts of mercapturic acid derivatives, such as N-acetyl-S-(3-oxobutyl)-l-cysteine (3CO-MA) and N-acetyl-S-(3-hydroxybutyl)-l-cysteine (3OH-MA), than TBTC or TBTO. On the other hand, DBTC and MBTC did not yield measurable amounts of 3CO-MA and/or 3OH-MA. The appearance of organotin metabolites in urine indicates that T3OH, T3CO, and hypothesized secondary metabolites, such as n-butyl(3-hydroxybutyl)(3-oxobutyl)tin chloride, n-butyl(3-hydroxybutyl)(4-hydroxybutyl)tin chloride, etc., are subject to the action of glutathione S-transferase to give mercapturic acid derivatives. These sulfur-containing metabolites (3CO-MA and 3OH-MA) were also found in control rat urine.