オガワ ムツミ    OGAWA Mutsumi
   小川 睦美
   所属
食健康科学部 健康デザイン学科
 
女性文化研究所 所属教員
 
現代ビジネス研究所 所属教員
 
生活機構研究科 生活科学研究専攻
 
女性健康科学研究所 所属教員
 
生活機構研究科 生活機構学専攻
   職種
教授
言語種別 英語
発行・発表の年月 2023/05
形態種別 学術雑誌
査読 査読あり
標題 Uniqueness of Tryptophan in the Transport System in the Brain and Peripheral Tissues
執筆形態 共著
掲載誌名 Food and Nutrition Sciences
掲載区分国外
巻・号・頁 2023(14),pp.401-414
担当区分 筆頭著者
著者・共著者 Mutsumi Ogawa, Fumiko Shimizu, Yukie Ishii, Tetsuya Takao, Akikazu Takada
概要 Amino acids are important substances that are transported to tissues such as the brain and muscles, and this process is considered insulin-dependent. However, it is not known to what extent each amino acid depends on insulin for transportation to tissues. Especially, tryptophan is important because it is converted to serotonin, melatonin, or kynurenine. After administering 50 grams of glucose or sucrose to young and middle-aged men, the levels of essential amino acids and branched-chain amino acids in the plasma of both young and middle-aged men decreased significantly with glucose and sucrose intake. Surprisingly, plasma levels of tryptophan did not decrease with glucose administration. In conclusion, not all amino acids are transported to tissues insulin-dependently upon administration of glucose or sucrose, and tryptophan is speculated to resist insulin-mediated transportation to tissues.