ナカニシ カズシゲ    NAKANISHI Kazushige
   中西 員茂
   所属
食健康科学部 管理栄養学科
 
生活機構研究科 生活科学研究専攻
 
生活機構研究科 生活機構学専攻
   職種
教授
言語種別 英語
発行・発表の年月 2017/03
形態種別 学術雑誌
査読 査読あり
標題 Changes in renal vessels associated with longterm administration of angiotensin converting enzyme inhibitor in Zucker fatty rats
執筆形態 共著
掲載誌名 J. Smooth Muscle Res 2017, 53
掲載区分国外
巻・号・頁 pp.20-30
著者・共著者 Kazushige Nakanishi, Yohko Nagai, Tatsuo Akimoto and Nobuaki Yamanaka
概要 In this study, we investigated renal afferent arteriolar changes induced by the long-term administration of an angiotensin converting enzyme inhibitor (ACEI) in Zucker fatty rats. Remarkable proliferative changes in the afferent arteriolar SMCs were frequently observed in the group given ACEI compared with the control group . It was indicated that long-term ACEI administration induced unusual proliferative changes in SMCs in afferent arterioles of ZFRs. These changes could reduce intraglomerular pressure by narrowing the lumens of afferent arterioles, but they could cause irreversible damage to the arterioles.