タカオ テツヤ    TAKAO Tetsuya
   高尾 哲也
   所属
食健康科学部 食安全マネジメント学科
 
生活機構研究科 生活科学研究専攻
 
国際文化研究所 所属教員
 
生活機構研究科 生活機構学専攻
 
女性健康科学研究所 所属教員
 
現代ビジネス研究所 所属教員
   職種
教授
言語種別 英語
発行・発表の年月 2014/08
形態種別 学術雑誌
査読 査読あり
標題 Lower expressions of the human bitter taste receptor TAS2R in smokers: reverse transcriptase-polymerase chain reaction analysis.
執筆形態 共著
掲載誌名 Tob Induc Dis.
巻・号・頁 12(1)
著者・共著者 Aoki M., Takao T., Takao K., Koike F., Suganuma N..
概要 Despite the fact that smokers have deficit in detecting taste, particularly bitter taste, no study has investigated its biological correlate. In this context, we compared the expression of the bitter taste receptor gene, taste 2 receptor (TAS2R) in the tongues of smokers and non-smokers. Tissue samples were collected from the lateral portion of the tongues of 22 smokers and 22 age- and gender-matched healthy volunteers (19 males and three females) with no history of smoking. Reverse transcriptase-polymerase chain reaction was used to examine the expression of TAS2R in the two groups, and the effect of aging on TAS2R expression was also assessed. TAS2R expression was significantly lower among smokers than non-smokers. Further, a positive correlation between age and expression of TAS2R was observed in non-smokers, but not smokers. This correlation difference was significant. Smokers showed a significantly lower expression of the bitter taste receptor gene than non-smokers, which is potentially caused by their inability to acquire such receptors with age because of cigarette smoking, in contrast to non-smokers.