ウメガキ ケイゾウ    UMEGAKI Keizo
   梅垣 敬三
   所属
生活科学部 食安全マネジメント学科
 
生活機構研究科 生活科学研究専攻
   職種
教授
言語種別 英語
発行・発表の年月 1984
形態種別 学術雑誌
査読 査読あり
標題 Impaired function of TXA2 and/or calcium in the platelets from SHRSP at hypertensive ages.
執筆形態 共著
掲載誌名 Thromb Res
掲載区分国外
巻・号・頁 35(2),pp.219-230
著者・共著者 Tomita, T., K. Umegaki, K. Nakamura, and E. Hayashi
概要 Aggregation of washed platelets from stroke-prone spontaneously hypertensive rats(SHRSP) was markedly reduced with the development of hypertension in comparison with age-matched normotensive Wistar Kyoto rats(WKY) (Tomita et al. Stroke 15, 70-75, 1984). The mechanism of the hypoaggregability of SHRSP platelets was studied.The results suggest that abnormalities of SHRSP platelets at hypertensive ages are due to an impaired function of thromboxane A2 and/or calcium concerned in aggregation and secretion but not due to a defect in cyclo-oxygenase and thromboxane synthetase pathway.