ウメガキ ケイゾウ    UMEGAKI Keizo
   梅垣 敬三
   所属
生活科学部 食安全マネジメント学科
 
生活機構研究科 生活科学研究専攻
   職種
教授
言語種別 英語
発行・発表の年月 2011
形態種別 学術雑誌
査読 査読あり
標題 Coleus forskohlii extract induces hepatic cytochrome P450 enzymes in mice.
執筆形態 共著
掲載誌名 Food Chem Toxicol
掲載区分国外
巻・号・頁 50(3-4),pp.750-755
著者・共著者 Virgona, N., Yokotani, K., Yamazaki, Y., Shimura, F., Chiba, T., Taki, Y., Yamada, S., Shinozuka, K., Murata, M., Umegaki K
概要 Coleus forskohlii root extract (CFE) is popular for use as a weight loss dietary supplement. In this study, the influence of standardized CFE containing 10% active component forskolin on the hepatic drug metabolizing system was investigated to evaluate the safety through its drug interaction potential. The results indicated the induction potential of CFE on CYPs, and that this effect was predominantly due to other, as yet unidentified constituents, and not forskolin contained in CFE.