タケヤマ エミコ TAKEYAMA Emiko
|標題||Dietary Intake of Green Nut Oil or DHA Ameliorates DHA Distribution in the Brain of a Mouse Model
of Dementia Accompanied by Memory Recovery Previous studies reported decreased levels of DHA and DHA-containing phosphatidylcholines in the brain of animals suffering from Alzheimer's disease,
|著者・共著者||◎Emiko Takeyama, Ariful Islam, Nakamichi Watanabe, Hiroe Tsubaki, Masako Fukushima, Md.Al Mamun, Shumpei Sato, Tomohito Sato, Fumihiro Eto, Ikuko Yao, Takashi K. Ito, Makoto Horikawa and Mitsutoshi Setou|
|概要||Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid, has significant health benefits. Previous studies reported decreased levels of DHA and DHA-containing phosphatidylcholines in the brain of animals suffering from Alzheimer's disease,the most common type of dementia; furthermore,DHA supplementation has been found to improve brain DHA levels and memory efficiency in dementia.
Oil extracted from the seeds ofPlukenetia volubilis (green nut oil; GNO)is also expected to have DHA like effects as it contains approximately 50% α-linolenic acid, a precursor of DHA.Despite this, changes in the spatial distribution of DHA in the brain of animals with dementia following GNO or DHA supplementation remain unexplored.In this study, desorption electrospray ionization imaging mass spectrometry (DESI-IMS)as applied to observe the effects of GNO or DHA supplementation upon the distribution of DHA in the brain of male senescence-accelerated
mouse-prone 8(SAMP8) mice, a mouse model of dementia. DESI-IMS revealed that brain DHA distribution increased 1.85-fold and 3.67-fold in GNO-fed and DHA-fed SAMP8 mice, respectively, compared to corn oil-fed SAMP8 mice. Memory efficiency in SAMP8 mice was also improved by GNO or DHA supplementation. In summary, this study suggests the possibility of GNO or DHA supplementation for the prevention of dementia.