タケヤマ エミコ    TAKEYAMA Emiko
   竹山 恵美子
   所属
食健康科学部 管理栄養学科
 
女性健康科学研究所 所属教員
 
生活機構研究科 生活科学研究専攻
   職種
教授
言語種別 英語
発行・発表の年月 2020/04
形態種別 学術雑誌
査読 査読あり
標題 Green Nut Oil or DHA Supplementation Restored
Decreased Distribution Levels of DHA Containing Phosphatidylcholines in the Brain of a Mouse Model of Dementia
執筆形態 共著
掲載誌名 Metabolites
掲載区分国外
出版社・発行元 MDPI
巻・号・頁 10,pp.153-164
著者・共著者 Ariful Islam, Emiko Takeyama, Md. Al Mamun, Tomohito Sato, Makoto Horikawa, Yutaka Takahashi, Kenji Kikushima and Mitsutoshi Setou
概要 Dementia is a major public health concern nowadays. Reduced levels of brain
docosahexaenoic acid (DHA) and DHA-phosphatidylcholines (DHA-PCs) in dementia patients
were reported previously. Recently, we have reported that supplementation of green nut oil (GNO) or
DHA improves memory function and distribution levels of brain DHA in senescence accelerated mice
P8 (SAMP8). GNO is extracted from Plukenetia volubilis seeds, and SAMP8 is a well-known model
mouse of dementia. In this current study, we examined the results of GNO or DHA supplementation
in the distribution levels of brain DHA-PCs in same model mouse of dementia using desorption
electrospray ionization (DESI) mass spectrometry imaging (MSI).We observed significantly decreased
distribution of brain DHA-PCs, PC (16:0_22:6), and PC (18:0_22:6) in SAMP8 mice compared to wild
type mice, and GNO or DHA treatment restored the decreased distribution levels of PC (16:0_22:6) and
PC (18:0_22:6) in the brain of SAMP8 mice. These results indicate that GNO or DHA supplementation
can ameliorate the decreased distribution of brain DHA-PCs in dementia, and could be potentially
used for the prevention and treatment of dementia.
researchmap用URL https://www.mdpi.com/2218-1989/10/4/153/pdf