ムラマツ シュキ MURAMATSU Shuki
|Epigenetic regulation involved in ethanol stress response in Saccharomyces cerevisiae.
|Yeast Genetics & Molecular Biology Meeting
|Fujimura S., Matsuda T., Suda H. and Nakagawa J.
|Eukaryotic cells encounter various environmental stresses that can cause growth inhibition or cell death. During fermentation process, yeast cells are exposed to various stresses such as oxidative, high sugar content, starvation and ethanol. Ethanol stress is one of the most common stresses and the cells should be equipped with appropriate mechanisms to avoid resulting damages. It has been shown that the expression of some genes is modified in response to ethanol. Among candidate genes involved in the ethanol stress response, we focused on the epigenetic regulation that is known as the gene regulatory mechanism through chromatin remodeling. ...In summary, it was demonstrated that HDACs and epigenetic factors are involved in the stress response against ethanol and other stresses. It would be worthwhile to further investigate the relationship between histone acetylation and expression pattern of the genes that alter in accordance with ethanol stress condition.