ムラマツ シュキ    MURAMATSU Shuki
   村松 朱喜
   所属
食健康科学部 健康デザイン学科
 
女性健康科学研究所 所属教員
   職種
専任講師
発表年月日 2009/07
発表テーマ The regulatory system of methanol metabolism by oxygen in methylotrophic yeast Pichia methanolica.
発表学会名 XXIVth International Conference on Yeast Genetics and Molecular Biology.
学会区分 国際学会
発表形式 ポスター
単独共同区分 共同
開催地名 Manchester, UK
発表者・共同発表者 Fujimura S., Nakagawa T., Matsufuji Y., Miyaji T., Tomizuka N. and Nakagawa J.
概要 In Pichia methanolica, expression of methanol-metabolic enzymes was strictly regulated by the presence of oxygen, and induction of alcohol oxidase (AOD) isozymes was largely dependent on oxygen concentrations. The proportion of AOD-isozyme species composing the octamerized AOD complex responded to oxygen conditions, e.g., under low oxygen condition, Mod1p was dominant, but with increasing oxygen concentration, the ratio of Mod2p increased. ... To find out whether histone acetylation plays a role in the regulation of AOD isozyme composition we tested the effect of histone decelases (HDACs) inhibitor. In this study we sought to understand the link between oxygen-mediated AOD regulation and histone modification.